Advantages of switching from non-standardized house dust extract to standardized house-dust mite in subcutaneous immunotherapy

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Immunotherapy of house dust mite allergy

House dust mite (HDM) is a predominant source of indoor aeroallergen worldwide, which induces allergic diseases including allergic rhinoconjunctivitis, allergic asthma, atopic eczema and other allergic skin diseases. Allergen specific immunotherapy (AIT) is the only potential disease-modifying treatment of HDM allergic subjects. However, AIT remains underused due to no universally accepted alle...

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SQ-standardized house dust mite immunotherapy as an immunomodulatory treatment in patients with asthma

BACKGROUND   Specific immunotherapy is the only treatment with the potential to prevent progression of the allergic disease and the potential to cure patients. The immunomodulatory ability of SQ-standardized house dust mite (HDM) subcutaneous immunotherapy (SCIT) was investigated in patients with allergic asthma. METHODS Fifty-four adults with HDM-allergic asthma were randomized 1:1 to receiv...

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Efficacy analysis of three-year subcutaneous SQ-standardized specific immunotherapy in house dust mite-allergic children with asthma

The present study aimed to evaluate the efficacy of three-year subcutaneous SQ-standardized specific immunotherapy (SCIT) in house dust mite (HDM)-allergic children with asthma. Ninety children with allergic asthma to HDMs, with or without allergic rhinitis, were randomly divided into two groups, the treatment group and the control group. The treatment group received SCIT combined with standard...

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House dust mite allergy

The importance of the allergens in sensitisation and disease can be readily demonstrated in regions with and without mite infestation. Dose-responce relationships in regions with high infestation are less easy to detect pointing to the importance of variations of other factors. The relationship between allergic disease and IgE antibody shows that only people with very high responses become pers...

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Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite

The house dust mite is one of the most common allergens worldwide. There is good evidence that house dust mite subcutaneous immunotherapy is efficacious and has long-term benefit in children. However, the evidence of the benefit of house dust mite sublingual immunotherapy (SLIT) is less convincing. The purpose of this meta-analysis was to evaluate that efficacy and safety of dust mite SLIT in c...

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ژورنال

عنوان ژورنال: Journal of Allergy and Clinical Immunology

سال: 2019

ISSN: 0091-6749

DOI: 10.1016/j.jaci.2018.12.184